Vardenafil hydrochloride trihydrate
Vardenafil hydrochloride trihydrate
CAS: 330808-88-3
Molecular Formula: C23H39ClN6O7S
Vardenafil hydrochloride trihydrate - Names and Identifiers
Vardenafil hydrochloride trihydrate - Physico-chemical Properties
| Molecular Formula | C23H39ClN6O7S |
| Molar Mass | 579.10976 |
| Solubility | ≥13.3 mg/mL in DMSO; ≥3.42 mg/mL in EtOH with gentle warming and ultrasonic; ≥95 mg/mL in H2O |
| Appearance | neat |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | Vadenine hydrochloride non-specifically inhibits PDE5 Mediated Hydrolysis of cGMP with an IC50 of 0.7 nM(6.6 nM). Vardenafi significantly enhanced SNP-induced relaxation of human trabecular smooth muscle at 3 nM(10 nM). Vardenafi significantly induced acetylcholine and electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil(100 mM) increased the level of hippocampal cGMP in rats. Vardenafil, tadalafil, and Sildenafil competitively inhibit the hydrolyzing phosphodiesterase 5(PDE5) of cGMP, thereby promoting the accumulation and relaxation of cGMP in vascular smooth muscle. |
| In vivo study | Vadinafil hydrochloride trihydrate dose-dependently induced the erectile response induced by intravenous injection of Nitroprusside Sodium salt in rabbits. Vardenafil(3 mg/kg, P. O.) caused alterations in object recognition ability in rats. Vardenafil(30 mg / L,p.o.) A simultaneous increase in the expression of iNOS and proliferating cell nuclear antigen (replication of SM cells) in rats was accompanied by a normalization of the rate of decline of dynamic corpus cavernosum fusion and the SM/collagen ratio. In rabbit hearts, Vardenafil induces a powerful preconditioning-like cardioprotective effect against ischemia/reperfusion injury by opening mitochondrial K(ATP) channels. Vardenafil protects against myocardial ischemia in reperfusion injury by relying on a mitochondrial K(ATP) channel opening mechanism. |
Vardenafil hydrochloride trihydrate - Risk and Safety
| UN IDs | UN 2811 6.1 / PGIII |
| HS Code | 2933595960 |
Supplier List
Featured ProductsSpot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Vardenafil hydrochloride trihydrate Request for quotationCAS: 330808-88-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Vardenafil hydrochloride trihydrate Request for quotationCAS: 330808-88-3
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Vardenafil hydrochloride trihydrate Visit Supplier Webpage Request for quotationCAS: 330808-88-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Vardenafil hydrochloride trihydrate
N-(PHOSPHONOMETHYL)IMINODIACETIC ACID MONOHYDRATE
1092491-37-6
calciumdicarbide
柠檬酸钠,二水
4-Methyl Phenyl Thioacetic
3'-deoxyguanosine
Decanal,2-methyl-
乙基磷氮酸二甲酯
WR-171,669
N-(PHOSPHONOMETHYL)IMINODIACETIC ACID MONOHYDRATE
1092491-37-6
calciumdicarbide
柠檬酸钠,二水
4-Methyl Phenyl Thioacetic
3'-deoxyguanosine
Decanal,2-methyl-
乙基磷氮酸二甲酯
WR-171,669